Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swines

• Autor(es):

  Udelsmann, Artur (UNICAMP. Department of Anesthesiology and Laboratory of Experimental Anesthesia);

  Silva, William Adalberto (UNICAMP. Center for Experimental Medicine and Surgery);

  Moraes, Ana Cristina de (UNICAMP. Center for Experimental Medicine and Surgery);

  Dreyer, Elisabeth (UNICAMP. Intensive Care Unit of the Hospital).

• Fonte:

  Acta Cirurgica Brasileira; volume 24, número 4, páginas 296-302. Agosto 2009.

• Assuntos:

  Poisoning;

  Hemodynamics;

  Anesthetics, Local;

  Swine.

• Resumo:

  PURPOSE: To compare the hemodynamic effects following a toxic dose of either agent after intravenous injection in swines, as might accidentally occur during regional anesthesia in humans. METHODS: Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization. After a 30-minute resting period, the animals were randomly divided into two groups in a double-blinded fashion and received a bolus intravenous injection of 4 mg.kg-1 of either agent. Hemodynamic results were evaluated at rest and 1, 5, 10, 15, 20 and 30 minutes after intoxication. RESULTS: Hemodynamic repressions of acute intoxication with levobupivacaine were more important and more prolonged than those of ropivacaína. CONCLUSION: In pigs, levobupivacaine was shown to be more toxic than ropivacaine when the same large doses are injected intravenously.

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