Effects of acetylsalicylic acid and acetic acid solutions in VX2 carcinoma cells: In vitro analysis

• Autor(es):

  Saad-Hossne, Rogerio (Paulista State University. Botucatu Medical School. Department of Surgery and Orthopedics);

  Prado, Renê Gamberini (Paulista State University. Botucatu Medical School. Department of Surgery and Orthopedics);

  Hossne, William Saad (Paulista State University. Botucatu Medical School).

• Fonte:

  Acta Cirurgica Brasileira; volume 21, número 3, páginas 151-154. Junho 2006.

• Assuntos:

  Carcinoma;

  Aspirin;

  Acetic Acid;

  In vitro.

• Resumo:

  PURPOSE: To analyze, in vitro, the effects of acetylsalicylic acid (aspirin) and acetic acid solutions on VX2 carcinoma cells in suspension and to examine the correlation between these effects and neoplastic cell death. METHODS: The VX2 tumor cells (10(7) cells/ml) were incubated in solutions containing differing concentrations (2.5% and 5%) of either acetylsalicylic acid or acetic acid, or in saline solution (controls). Every five minutes, cell viability was tested (using the trypan blue test) and analyzed under light microscopy. RESULTS: Tumor cell viability (in %) decreased progressively and, by 30 minutes, neoplastic cell death had occurred in all solutions. CONCLUSION: Based on this experimental model and the methodology employed, we conclude that these solutions cause neoplastic cell death in vitro.

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