Chronic Chagas disease patients with sinus node dysfunction: is the presence of IgG antibodies with muscarinic agonist action independent of left ventricular dysfunction?

• Autor(es):

  Altschüller, Maria Beatriz Corrêa de Mello (Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Cardiologia);

  Pedrosa, Roberto Coury (Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Cardiologia);

  Pereira, Basílio de Bragança (Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Comissão de Investigação Científica);

  Corrêa Filho, Wilson Braz (Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Cardiologia);

  Medeiros, Aline Silva de (Universidade Federal do Rio de Janeiro. Programas de Pesquisa em Engenharia);

  Costa, Patrícia Cristina Santos (Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho);

  Carvalho, Antonio Carlos Campos de (Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho).

• Fonte:

  Revista da Sociedade Brasileira de Medicina Tropical; volume 40, número 6, páginas 665-671. Dezembro 2007.

• Assuntos:

  Chagas’ disease;

  Molecular mimicry;

  Sinus node dysfunction;

  Muscarinic receptors;

  Autonomic dysfunction.

• Resumo:

  Studies have shown that muscarinic agonist IgG antibodies from Chagas disease patients alter the electrical activity of cardiac cells in vitro. Others have considered their presence, along with sinus node dysfunction, to be consequences of progressive cardiac lesions. The aim of this study was to evaluate the relationship between these antibodies and sinus node and left ventricular dysfunction in 65 chronic Chagas disease patients. These patients were divided into group I, composed of 31 patients with sinus node dysfunction, and group II, composed of the patients without this syndrome. Data analysis using the log linear model showed interdependence between sinus node dysfunction and the antibodies (p = 0.0021) and between nodal and ventricular dysfunction (p = 0.0005). However, no relationship was found between the antibodies and ventricular function. Age and sex did not influence any other variables. The chronic Chagas disease patients with sinus node dysfunction had higher prevalence of muscarinic agonist antibodies, independent of the presence of myocardial dysfunction.

• Acesse o texto completo (Português)