Endocrine and morphological assessment of ovarian homologous transplantation

• Autor(es):

  Petroianu, Andy (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto, Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Cirurgia, Universidade Federal do Estado de São Paulo. Escola Paulista de Medicina);

  Alberti, Luiz Ronaldo (Hospital Júlia Kubitschek de Belo Horizonte);

  Vasconcellos, Leonardo de Souza (Hospital das Clínicas de Minas Gerais);

  Leite, Juliana Moysés (Hospital Mater Dei de Belo Horizonte);

  Castro, Lúcia Porto Fonseca de (UFMG. Faculdade de Medicina).

• Fonte:

  Jornal Brasileiro de Patologia e Medicina Laboratorial; volume 40, número 3, páginas 206-211. Junho 2004.

• Assuntos:

  Ovarian hormones;

  Ovary transplantation;

  Ovarian histology;

  Rabbits;

  Cyclosporine.

• Resumo:

  INTRODUCTION: Ovarian failure may be due to bilateral oophorectomy on several ovarian diseases, such as infection and neoplasm; chemo and radiotherapy as well as factors related to age led to endocrine disturbances followed by systemic complications. OBJECTIVES: To assess endocrine and histological ovarian aspects following allogeneic ovarian transplantation without vascular pedicle and immunosupressed by cyclosporine. MATERIAL AND METHOD: Twelve female New Zealand White and California rabbits were divided into 2 Groups: group 1 (n = 4), sham operation; and group 2 (n = 8), submitted to a laparotomy and ovarian bilateral transplantation between pairs of animals. In one side the ovary was intact and in the other side the ovary was sliced. At the end of the follow-up period, blood samples were studied for estradiol, progesterone, FSH and LH. At the end of the experiment, histological studies of ovaries, uterus and tubes were carried out. RESULTS: The ovary implants were surrounded by connective tissue; they were well vascularized, and presented follicles in different stages of development. Hormonal values were normal in all rabbits. CONCLUSIONS: Allogeneic orthotopic ovarian transplantation without vascular pedicle and immunosupressed by cyclosporine was effective to preserve normal level of ovarian hormone.

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